· Turmeric has been in India for thousands of years as a spice and medicinal herb. Recently, science has started to back up what the Indians have known for a long time- it really does contain compounds with medicinal properties. These compounds are called curcuminoids, the most important of which is curcumin. Curcumin is the main active ingredient in turmeric. It has powerful anti-inflammatory effects and is a very strong antioxidant.
· Inflammation is incredibly important. It helps the body fight foreign invaders and also has a role in repairing damage. Without inflammation, pathogens like bacteria could easily take over our bodies and kills us. Although acute (short-term) inflammation is beneficial, it can become a major problem when it is chronic (long-term) and inappropriately deployed against the body’s own tissues.
· It is now believed that chronic, low-level inflammation plays a major role in almost every chronic, Western disease. This includes heart disease, cancer, metabolic syndrome, Alzheimer’s and various degenerative conditions. Therefore, anything that can help fight chronic inflammation is of potential importance in preventing and even treating these diseases. Curcumin is a bioactive substance that fights inflammation at the molecular level. Curcumin blocks NF-kB, a molecule that travels into the nuclei of cells and turns on genes related to inflammation. NF-kB is believed to play a major role in many chronic diseases. In several studies, its potency has compared favorably to anti-inflammatory pharmaceutical drugs, except without the side effects.
· Oxidative damage is believed to be another of the mechanisms behind ageing and many diseases. It involves free radicals, highly reactive molecules with unpaired electrons. Free radicals tend to react with important organic substances, such as fatty acids, proteins or DNA. The main reason antioxidants are so beneficial is that they protect our bodies from free radicals. Curcumin delivers a one-two punch against free radicals. It happens to be a potent antioxidant that can neutralize free radicals due to its chemical structure, and also boosts the activity of the body’s own antioxidant enzymes.
· Curcumin also plays a role in the brain. Neurons are capable of forming new connections, but in certain areas of the brain, they can also multiply and increase in number. One of the main drivers of this process is Brain-Derived Neurotrophic Factor (BDNF), which is a type of growth hormone that functions in the brain. Many common brain disorders have been linked to decreased levels of this hormone. This includes depression and Alzheimer’s disease. Curcumin can increase brain levels of BDNF. By doing this, it may be effective at delaying or even reversing many brain diseases and age-related decreases in brain function. Studies show that curcumin also has incredible benefits against depression. Depression is linked to reduced levels of brain-derived neurotrophic factor and a shrinking hippocampus, a brain area with a roe in learning and memory. Curcumin boosts BNDF levels, potentially reversing some of these changes. There is also some evidence that curcumin can boost the brain neurotransmitters serotonin and dopamine.
· Heart disease is the biggest killer in the world. Curcumin may help reverse many steps in the heart disease process. Perhaps the main benefit of curcumin when it comes to heart disease, is improving the function of the endothelium, which is the lining of the blood vessels. It is well known that the endothelial dysfunction is a major driver of heart disease and involved an inability of the endothelium to regulate blood pressure, blood clotting and various other factors. Several studies suggest that curcumin leads to improvements in endothelial function. Curcumin also reduces inflammation and oxidation, which are also important in hear disease.
· Turmeric may also help prevent (and perhaps even treat) cancer. There are many different forms of cancer, but they do have several commonalities, some of which appear to be affected by curcumin supplementation. Researchers have been studying curcumin as a beneficial herb in cancer treatment. Studies show that curcumin has the potential to affect cancer growth, development and spread at the molecular level, reducing angiogenesis (growth of new blood vessels in tumors), metastasis (spread of cancer), as well as contributing to the death of cancerous cells. Multiple studies have shown that curcumin can reduce the growth of cancerous cells in the laboratory and inhibit the growth of tumors in test animals. Whether high-dose curcumin (preferably with an absorption enhancer like pepper) can help treat cancer in humans has yet to be tested properly. However, there is some evidence that it may help prevent cancer from occurring in the first place, especially cancers of the digestive system (like colorectal cancer).
· Alzheimer’s disease is the most common neurodegenerative disease in the world and a leading cause of dementia. Curcumin has been shown to cross the blood-brain barrier. It is known that oxidative damage play a role in Alzheimer’s disease. As we know, curcumin has beneficial effects on both. One key feature of Alzheimer’s disease is a buildup of protein tangles called Amyloid plaques. Studies show that curcumin can help clear these plaques.
Expert Rev Neurother. 2015 Jun;15(6):629-37. doi: 10.1586/14737175.2015.1044981.
Clinical development of curcumin in neurodegenerative disease.
J Clin Psychopharmacol. 2015 Aug;35(4):406-10. doi: 10.1097/JCP.0000000000000352.
Chronic Supplementation of Curcumin Enhances the Efficacy of Antidepressants in Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
Nutrients. 2015 Aug 12;7(8):6719-38. doi: 10.3390/nu7085307.
Diet-Induced Cognitive Deficits: The Role of Fat and Sugar, Potential Mechanisms and Nutritional Interventions.
J Inorg Biochem. 2016 Feb 27. pii: S0162-0134(16)30056-3. doi: 10.1016/j.jinorgbio.2016.02.029. [Epub ahead of print]
A gallium(III) Schiff base-curcumin complex that binds to amyloid-β plaques.
Molecules. 2015 May 20;20(5):9183-213. doi: 10.3390/molecules20059183.
Curcumin, inflammation, and chronic diseases: how are they linked?
Curr Pharmacol Rep. 2015 Apr;1(2):129-139. Epub 2015 Jan 30.
"Curcumin, the King of Spices": Epigenetic Regulatory Mechanisms in the Prevention of Cancer, Neurological, and Inflammatory Diseases.
J Stroke Cerebrovasc Dis. 2016 Feb 26. pii: S1052-3057(16)00021-5. doi: 10.1016/j.jstrokecerebrovasdis.2016.01.008. [Epub ahead of print]
Curcumin Attenuates Inflammation, Oxidative Stress, and Ultrastructural Damage Induced by Spinal Cord Ischemia-Reperfusion Injury in Rats.
Planta Med. 2016 Mar 22. [Epub ahead of print]
Effect of Ginger and Turmeric Rhizomes on Inflammatory Cytokines Levels and Enzyme Activities of Cholinergic and Purinergic Systems in Hypertensive Rats.
Akinyemi AJ1, Thomé GR2, Morsch VM2, Bottari NB2, Baldissarelli J2, de Oliveira LS2, Goularte JF3, Belló-Klein A3, Duarte T4, Duarte M4, Boligon AA5, Athayde ML5, Akindahunsi AA1, Oboh G1, Schetinger MR2.
· Ginger is a flowering plant that originated from China. It belongs to the Zingiberaceae family, and is closely related to turmeric, cardamom, and galangal. The rhizome (underground part of the stem) is the part commonly used as a spice.
· Ginger is one of the very few “superfoods” that are actually worthy of that term. Ginger contains gingerol, a substance with powerful medicinal properties. Gingerol is the main bioactive compound in ginger, responsible for much of its medicinal properties. It has powerful anti-inflammatory and antioxidant effects.
· Ginger appears to be highly effective against nausea. It has a long history of use as a sea sickness remedy. It may be most effective when it comes to pregnancy-related nausea, such as morning sickness, but ginger may also relieve nausea and vomiting after surgery, and in cancer patients undergoing chemotherapy
· The active ingredient in ginger can also help fight infections. Ginger extract can inhibit the growth of many different types of bacteria. It is very effective against the oral bacteria linked to inflammatory diseases in the gums, such as gingivitis and periodontitis. Fresh ginger may also be effective against the RSV virus, a common cause of respiratory infections.
· Ginger has been known to be effective against exercise-induced muscle pain. Ginger does not have an immediate impact, but may be effective at reducing the day-to-day progression of muscle pain- These effects are believed to be mediated by the anti-inflammatory properties. The anti-inflammatory effects can also help with osteoarthritis - this involves degeneration of the joints in the body, leading to symptoms like joint pain and stiffness
· Ginger may lower cholesterol levels. High levels of LDL lipoproteins (the “bad” cholesterol) are linked to an increased risk of heart disease. The foods you eat can have a strong influence on LDL levels. Ginger can lead to significant reductions In LDL cholesterol and blood triglyceride levels
· Ginger contains a substance that may help prevent cancer- the anti-cancer properties are attributed to 6-gingerol, a substance that is found in large amounts of raw ginger. There is some, albeit limited, evidence that ginger may be effective against pancreatic cancer, breast cancer, and ovarian cancer
· Ginger may improve brain function and protect against Alzheimer’s disease- oxidative stress and chronic inflammation can accelerate the aging process. They are believed to be among the key drivers of Alzheimer’s disease and age-related cognitive decline. Some studies in animals suggest that the antioxidants and bioactive compounds in ginger can inhibit inflammatory responses that occur in the brain. There is also some evidence that ginger can enhance brain function directly. There are also numerous studies in animals showing that ginger can protect against age-related decline in brain function.
· Ginger may drastically lower blood sugars and improve heart disease risk factors, help treat chronic indigestion, and significantly reduce menstrual pain
J Sci Food Agric. 2014 Nov;94(14):2972-7. doi: 10.1002/jsfa.6642. Epub 2014 Apr 7.
Anti-obesity action of gingerol: effect on lipid profile, insulin, leptin, amylase and lipase in male obese rats induced by a high-fat diet.
Drug Des Devel Ther. 2015 Nov 9;9:6019-26. doi: 10.2147/DDDT.S94346. eCollection 2015.
6-Gingerol alleviates exaggerated vasoconstriction in diabetic rat aorta through direct vasodilation and nitric oxide generation.
Oncotarget. 2015 Dec 22;6(41):43310-25. doi: 10.18632/oncotarget.6383.
Proteasome inhibition mediates p53 reactivation and anti-cancer activity of 6-gingerol in cervical cancer cells.
J Diet Suppl. 2016 Jul 3;13(4):433-48. doi: 10.3109/19390211.2015.1107802. Epub 2015 Dec 16.
6-Gingerol-Rich Fraction from Zingiber officinale Prevents Hematotoxicity and Oxidative Damage in Kidney and Liver of Rats Exposed to Carbendazim.
Phytother Res. 2016 Jan 7. doi: 10.1002/ptr.5561. [Epub ahead of print]
6-Gingerol Mediates its Anti Tumor Activities in Human Oral and Cervical Cancer Cell Lines through Apoptosis and Cell Cycle Arrest.
J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 1;1011:99-107. doi: 10.1016/j.jchromb.2015.12.051. Epub 2016 Jan 4.
Separation and preparation of 6-gingerol from molecular distillation residue of Yunnan ginger rhizomes by high-speed counter-current chromatography and the antioxidant activity of ginger oils in vitro.
Phytomedicine. 2016 Feb 15;23(2):200-13. doi: 10.1016/j.phymed.2015.12.013. Epub 2016 Jan 5.
Bioactive compounds isolated from apple, tea, and ginger protect against dicarbonyl induced stress in cultured human retinal epithelial cells.
Pharm Biol. 2016 Mar 18:1-10. [Epub ahead of print]
6-Gingerol inhibits Vibrio cholerae-induced proinflammatory cytokines in intestinal epithelial cells via modulation of NF-κB.
Biochem Biophys Res Commun. 2015 Nov 27;467(4):1090-6. doi: 10.1016/j.bbrc.2015.09.074. Epub 2015 Oct 9.
Activation and modulation of recombinantly expressed serotonin receptor type 3A by terpenes and pungent substances.
Complement Ther Med. 2015 Dec;23(6):827-31. doi: 10.1016/j.ctim.2015.10.002. Epub 2015 Oct 30.
Investigating the effects of inhaling ginger essence on post-nephrectomynausea and vomiting.
J Community Support Oncol. 2016 Jan;14(1):11-20. doi: 10.12788/jcso.0206.
New therapies for antiemetic prophylaxis for chemotherapy.
Can Fam Physician. 2016 Feb;62(2):145.
Ginger for nausea and vomiting of pregnancy.
- Lion’s Mane is a medicinal mushroom and powerful superfood for the brain, nerves, and immune system. Used in Asia for thousands of years, it is said to give one “nerves of steel and the memory of a lion”.
- It is known for its powerful effects as a brain tonic, and is rumored to have been used as a tea for centuries by Buddhist monks to enhance brain power and heighten their ability to -concentrate during mediation. Unlike any other food substance known, the mushroom has been studied to be extremely effective at encouraging and inducing Nerve Growth Factor in the brain. Lion’s Mane is a potent catalyst for brain tissue regeneration and helps to improve memory and cognitive functions. The mushrooms was proven effective for its ability to efficiently stimulate neuron growth, improving muscle-motor response pathways in Parkinson’s and repairing neurological trauma in stroke victims. Lion’s mane mycelium has been studied to reduce amyloid plaques that interfere with brain neurotransmission, which is thought to play a role in Alzheimer’s and various neurodegenerative disorders, like Parkinson’s. It may also be effective as a treatment for helping to eliminate the spirochaete bacteria in the brain.
- Lion’s Mane is considered by many people to be the perfect superfood for those who have experienced seizures because of this ability to elicit nerve regeneration. It can be extremely helpful for those with epilepsy or who have experienced Gran-mal seizures, both of which are thought to cause nerve cell injury in the brain and affect cognitive function.
- Lion’s mane may also be good for depression. Some people are calling it the “smart mushroom” for its possible effects on increasing cognition functions, memory as well as its potential as an antidepressant. Nerve Growth Factor is thought to play an important role in helping to elevate ones mood, alleviate anxiety and lessen the chances of depression.
- Lion’s Mane, like other medicinal mushrooms, contains high amounts of antioxidants. These health components are powerful immune-modulators that support “deep immune health”. The specific active ingredients are also being research for their effects at decreasing tumor growth.
- Lion’s mane can be helpful for problems of the digestive tracts such as stomach and duodenal ulcers, as well as for cancers of the sophagus, stomach, and duodenum. The mushroom extract is approved by the Chinese Ministry of Health for Chronic Superficial Gastritis treatment. Its digestive tonic effects are most likely due to the presence of beta glucan polysaccharides, along with polypeptides and fatty acids. These substances also enhance the function of the gastric mucus barrier, important for a healthy colon and digestive tract. Research has shown that these polysaccharides, along with adenosince and oleanolic acids, stimulate the induction of interferons and modulation of the immune system. This in turn boosts the white blood cell count and helps to heal stomach related conditions.
- Source: http://www.superfoods-for-superhealth.com/lions-mane.html
- Shiitake mushrooms provide B-complex vitamins that benefit your metabolism by helping your body convert food into energy. B vitamins also help your body make red blood cells, protecting you from developing anemia. If you are trying to increase your intake of essential minerals, adding shiitake mushrooms is a flavorful way to supplement your diet.
· Shiitake mushrooms have ant-cancer properties, according to Japanese researchers who published a study in “Cancer Science” in 2011. The research team gave a powdered shiitake extract to mice with melanoma and found that their tumors stopped growing. Shiitake extract appears to restore melanoma-reactive T cells, an important aspect of cancer treatment.
· Shiitake mushrooms also contain strong compounds having the natural ability to discourage inflammation, tumors, “bad” bacteria, harmful viruses, and fungus.
- The maitake mushroom is a large mushroom native to North America, Europe, and Japan. Maitake mushrooms have been used as both food and medicine in Asian cultures for many centuries. Maitake mushrooms are traditionally believed to promote longevity.
- Maitakes contain a polysaccharide called beta glucan. Maitake D-fraction may help attack cancer cells and help ease the many side effects of chemotherapy. A 1997 study in the Annals of the New York Academy of Science found that maitake D-fraction helped prevent the spread of breast cancer tumors in mice, and a June 2011 study published in the Journal of Medicinal Food found that maitake D-fraction helped lead to the death of breast cancer cells. The Feb/March 1996 Townsend Letter for Doctors and Patients reported that “Maitake mushroom was found effective against leukemia and stomach and bone cancers,” and that maitake D-fraction helped provide relief from the nausea and hair loss associated with chemotherapy. More recently, a study published in Cancer, Immunology, Immunotherapy in October 2010 showed that maitake mushroom inhibited colon cancer. A 1995 study in the Annals of the New York Academy of Science found that maitake D-fraction boosted the immune systems of mice injected with liver cancer cells, and the 1997 study mentioned above found that maitake D-fraction enhanced immune function in mice implanted with breast cancer. Further, a study published in the Summer 2004 issue of the Journal of Medicinal Food found that maitake D-fraction activated immune cells and might help fight infection.
- People with Type 2 diabetes may also benefit from maitake mushrooms, which may help manage blood glucose levels and reduce insulin resistance. A study published in the April 2007 issue of the Journal of Pharmacy and Pharmacology showed that MT-alpha-glucan, another polysaccharide found in maitakes, decreased insulin levels and fasting blood glucose. Since maitakes may lower blood sugar levels, you should be careful about eating maitake mushrooms if you are taking diabetes medications.
- Many doctors in Japan use maitake mushrooms to lower blood pressure and blood lipids, two key risk factors in cardiovascular disease. Moreover, a study published in the October 2011 issue of the Journal of Agriculture and Food Chemistry showed that maitake mushroom extract supplementation lowered cholesterol levels in the liver.
- Source: http://www.healthcastle.com/herb_mushroom_maitake.shtml
Int J Med Mushrooms. 2014;16(2):179-87.
Inhibitory activity of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher Basidiomycetes) on transformed cells by human papillomavirus.
Tumour Biol. 2014 Oct;35(10):9919-26. doi: 10.1007/s13277-014-2217-1. Epub 2014 Jul 6.
A chemically sulfated polysaccharide derived from Ganoderma lucidum induces mitochondrial-mediated apoptosis in human osteosarcoma MG63 cells.
Int J Med Mushrooms. 2014;16(4):345-54.
Wound healing activity of an aqueous extract of the Lingzhi or Reishimedicinal mushroom Ganoderma lucidum (higher Basidiomycetes).
Integr Cancer Ther. 2015 May;14(3):249-57. doi: 10.1177/1534735414568721. Epub 2015 Jan 27.
Ganoderma lucidum for cancer treatment: we are close but still not there.
Nutr Cancer. 2015;67(3):373-91. doi: 10.1080/01635581.2015.1004731. Epub 2015 Mar 26.
The impact of complementary and alternative medicines on cancersymptoms, treatment side effects, quality of life, and survival in women with breast cancer--a systematic review.
Int J Med Mushrooms. 2015;17(12):1171-7.
Antioxidant Potential of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) Cultivated on Artocarpus heterophyllus Sawdust Substrate in India.
Dermatol Ther (Heidelb). 2016 Mar;6(1):105-9. doi: 10.1007/s13555-016-0099-4. Epub 2016 Feb 11.
Resolution of Cutaneous Sarcoidosis Following Topical Application of Ganoderma lucidum (Reishi Mushroom).
· Kelp is a type of large brown seaweed that grows in shallow, nutrient-rich saltwater, near coastal fronts around the world.
· Because it absorbs the nutrients from its surrounding marine environment, kelp is rich in vitamins, minerals, trace elements, enzymes. Kelp is often considered a ‘superfood’ due to its significant mineral content. It’s especially concentrated in iodine, which is important for optimal thyroid function and metabolism. A deficiency in iodine leads to metabolism disruption and can also lead to an enlargement of the thyroid gland known as goiter. However, overconsumption can create health issues too. The key is to get a moderate amount to raise energy levels and brain functioning.
· Kelp also contains notable amounts of iron, manganese, calcium, magnesium, copper, zinc, riboflavin, niacin, thiamin, vitamins A, B-12, B-6, and C. The benefits of these vitamins and nutrients are substantial. B vitamins in particular are essential for cellular metabolism and providing your body with energy. According to UCSF Medical Center, kelp has more calcium than many vegetables including kale and collard greens. Calcium is important to maintain strong bones and optimal muscle function.
· Inflammation and stress are considered risk factors for many chronic diseases- Kelp is naturally high in antioxidants, including carotenoids, flavonoids, and alkaloids, which help fight against disease-causing free radicals.
· Antioxidant vitamins like vitamin C, and minerals like manganese and zinc, help to combat oxidative stress and may offer benefits to cardiovascular health. There have been many claims regarding kelp’s abilities to fight chronic disease, including cancer.
· Recent studies have explored the role of sea vegetables in estrogen-related and colon cancers, osteoarthritis, and other conditions. Researchers found that kelp can slow the spread of colon and breast cancers. A compound found in kelp called fucoidan may also prevent the spread of lung cancer and prostate cancer. This doesn’t mean that kelp should be used to cure any diseases or be considered a guaranteed protection against disease.
· Kelp contains a natural fiber called alginate, which suggests that it may halt the absorption of fat in the gut. Kelp may have great potential for diabetes and obesity.
- Source: http://www.healthline.com/health/food-nutrition/benefits-of-kelp
· Alaria comes from the coasts of the North Atlantic (France, Scotland, Ireland, Greenland, Iceland, northeastern U.S., northeastern Canada), the North Sea (England, Norway, Netherlands), Novaya Zemlya to the North Pacific (Bering Sea and Sea of Japan)
· Alaria has the most significant amounts of calcium, magnesium, and B-vitamins of any edible seaweed. Coming from the sea, Alaria is a rich source of organic trace minerals in a form that is very easily assimilated. No land plant can compare. Iodine deficiency is commonplace and land plants typically do not supply the amount of iodine needed to meet our needs. Inorganic iodine added to table salt is not an ideal form.
· Alaria, as do most seaweeds, inhibit cancer cell growth in animal studies. It is considered anti-mutagenic, and anti-tumor. It is postulated that the low rate of breast cancer and lung cancer in Japan (even despite the high rate of smoking) is due to seaweed consumption. Seaweeds can lower serum cholesterol levels as well as blood pressure and help remove arterial plaque as well as decrease platelet stickiness. Alaria and certain other seaweeds can also lower raised uric acid levels and can be anti-bacterial, anti-fungal, and anti-viral.
· Alaria can be very effective in preventing damage due to radiation exposure from power plants, nuclear test, etc (this radiation can virtually travel around the globe in small amounts and effect our health). It may also be very valuable in people undergoing radiation therapy, as it may decrease side effects and increase recovery speed.
· Alaria has also been shown to favorably alter both estrogen and phytoestrogen levels in the body. In addition to helping return hormone levels to normal, it could also play a role in helping to prevent breast cancer in post menopausal women. Any women or men with increased estrogen levels or altered hormonal balance should consider eating alaria.
· Two very important components of alaria: algin and fucoidan. Algin is a great binder of heavy metals from the GI tract. It can help in removing toxic metals and chemicals from the body. Fucoidan is an anti-inflammatory component of alaria. It is an immune stimulant, but more importantly, it can speed up the healing response after physical traumas and surgery. Fucoidan breaks down into fucose, a natural sugar found to have receptor sites on human cells, suggesting it is an essential nutrient.
- Source: http://supremenutritionproducts.com/AlariaSupreme/index.html